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Melatonin Protects Against Rotenone-induced Oxidative Stress in a Hemiparkinsonian Rat Model

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Title Melatonin Protects Against Rotenone-induced Oxidative Stress in a Hemiparkinsonian Rat Model
 
Creator Saravanan, Karuppagounder S
Sindhu, Kizhake M
Mohanakumar , K P
 
Subject Cell Biology & Physiology
 
Description In the present study, we evaluated the effect of melatonin, a wellknown free radical scavenger and neuroprotector, against rotenone-induced oxidative stress in a hemiparkinsonian rat model. The effect of melatonin on
glutathione (GSH) depletion caused by unilateral, intranigral infusion of rotenone was investigated employing a spectrofluorimetric procedure. We also studied the effect of melatonin on rotenone-induced changes in the antioxidant enzymes superoxide dismutase (SOD) and catalase in the
cytosolic fractions of substantia nigra (SN), employing spectrophotometric procedures. Rotenone-induced hydroxyl radicals (•OH) in the isolated mitochondria, as measured employing a sensitive HPLC-electrochemical
method, were significantly scavenged by melatonin. Melatonin treatment restored the rotenone-induced decrease in GSH level and changes in antioxidant enzyme (SOD and catalase) activities in the SN. Our results
strongly indicate melatonin’s beneficial use in Parkinson’s disease therapy as an antioxidant.
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/343/1/JOURNAL_OF_PINEAL_RESEARCH%2C_42(_3)%2C_247%2D253%2C2007[100].pdf
Saravanan, Karuppagounder S and Sindhu, Kizhake M and Mohanakumar , K P (2007) Melatonin Protects Against Rotenone-induced Oxidative Stress in a Hemiparkinsonian Rat Model. Journal of Pineal Research, 42 (3). pp. 247-253.
 
Relation http://dx.doi.org/10.1111/j.1600-079X.2006.00412.x
http://www.eprints.iicb.res.in/343/