ICAR Research Data Repository for Knowledge Management
Molecular Mechanism of Insulin Resistance
EPrints@IICB
View Archive Info| Field | Value | |
| Title |
Molecular Mechanism of Insulin Resistance
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| Creator |
Bhattacharya, Samir
Dey, Debleena Roy, Sib Sankar |
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| Subject |
Cell Biology & Physiology
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| Description |
Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby causing insulin resistanceNand type 2 diabetes. However, the underlying mechanism involved is still unclear. In searching for the cause of the mechanism, it has been found that palmitate inhibits insulin receptor (IR) gene expression, leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKCĪµ causes this reduction in insulin receptor gene expression. One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies. We provide an overview of this important area, emphasizing the current status.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/353/1/JOURNAL_OF_BIOSCIENCES%2C__32_(_2)%2C405%2D413%2C2007[108].pdf
Bhattacharya, Samir and Dey, Debleena and Roy, Sib Sankar (2007) Molecular Mechanism of Insulin Resistance. Journal of Biosciences, 32 (2). pp. 405-413. |
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| Relation |
http://dx.doi.org/10.1007/s12038-007-0038-8
http://www.eprints.iicb.res.in/353/ |
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