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Leishmania donovani Bisubunit Topoisomerase I Gene Fusion Leads to an Active Enzyme with Conserved Type IB Enzyme Function

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Title Leishmania donovani Bisubunit Topoisomerase I Gene
Fusion Leads to an Active Enzyme with Conserved Type IB
Enzyme Function
 
Creator Das, Benu Brata
Bose Dasgupta, Somdeb
Ganguly, Agneyo
Mazumder, Saumyabrata
Roy, Amit
Majumder, Hemanta K
 
Subject Infectious Diseases and Immunology
 
Description All eukaryotic topoisomerase I enzymes are monomeric enzymes, whereas the kinetoplastid family (Trypanosoma and Leishmania) possess an unusual bisubunit topoisomerase I. To determine what happens to the enzyme architecture and catalytic property if the two subunits are fused, and to
explore the functional relationship between the two subunits, we describe here in vitro gene fusion of Leishmania bisubunit topoisomerase I into a
single ORF encoding a new monomeric topoisomerase I (LdTOPIL-fus-S).
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/387/1/FEBS_JOURNAL%2C_274_(1)%2C__150%2D163_%2C2007_[133].pdf
Das, Benu Brata and Bose Dasgupta, Somdeb and Ganguly, Agneyo and Mazumder, Saumyabrata and Roy, Amit and Majumder, Hemanta K (2007) Leishmania donovani Bisubunit Topoisomerase I Gene Fusion Leads to an Active Enzyme with Conserved Type IB Enzyme Function. FEBS Journal , 274 (1). pp. 150-163.
 
Relation http://dx.doi.org/10.1111/j.1742-4658.2006.05572.x
http://www.eprints.iicb.res.in/387/