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MAOA Promoter Polymorphism and Attention Deficit Hyperactivity Disorder (ADHD) in Indian Children

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Title MAOA Promoter Polymorphism and Attention Deficit
Hyperactivity Disorder (ADHD) in Indian Children
 
Creator Das, Manali
Das Bhowmik, Aneek
Sinha, Swagata
Chattopadhyay, Anindita
Chaudhuri, Keya
Singh, Manoranjan
Mukhopadhyay, Kanchan
 
Subject Molecular & Human Genetics
 
Description Attention deficit hyperactivity disorder (ADHD)
is a highly disabling, early onset childhood neurobehavioral
disorder with a higher occurrence in
boys as compared to girls. Pharmacological and
molecular genetic studies have revealed the
influence of dopaminergic and serotonergic systems
in the etiology of the disorder. Monoamine
oxidase A (MAOA) is a mitochondrial enzyme that
regulates the dopaminergic signals in the presynaptic
region. Polymorphism in the promoter
region of theMAOAgene, which comprises of 30 bp
repeats with repeat number varying between 2.5,
3.5, 4.5, and 5.5, has been shown to be associated
with various neurobehavioral disorders including
ADHD. This is the first study on Indian ADHD
cases to validate an association between transmission
of MAOA promoter polymorphism and
risk of ADHD. We have analyzed the MAOA
promoter polymorphism in a group of ADHD
probands, their parents and ethnically matched
controls by UNPHASED. Our findings indicate
significant difference in the frequency of 3.5
repeat allele (P¼0.02) between cases and controls
and preferential transmission of the short allele
(3.5 repeat) from mothers to maleADHDprobands
(P¼0.005). We conclude that the short 3.5 repeat
allele of the MAOA-u VNTR is probably associated
with ADHD in our population and could be the
reason for making boys prone to ADHD as compared
to girls.
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/403/1/AMERICAN_JOURNAL_OF_MEDICAL_GENETICS_PART_B%2DNEUROPSYCHIATRIC_GENETICS%2C_141B(6)637%2D642_[38].pdf
Das, Manali and Das Bhowmik, Aneek and Sinha, Swagata and Chattopadhyay, Anindita and Chaudhuri, Keya and Singh, Manoranjan and Mukhopadhyay, Kanchan (2006) MAOA Promoter Polymorphism and Attention Deficit Hyperactivity Disorder (ADHD) in Indian Children. American Journal of Medical Genetics, 141B (6). pp. 637-642.
 
Relation http://dx.doi.org/10.1002/ajmg.b.30385
http://www.eprints.iicb.res.in/403/