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Antidiabetic, Antioxidant and Antihyperlipidemic Status of Heliotropium zeylanicum Extract on Streptozotocin-Induced Diabetes in Rats

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Title Antidiabetic, Antioxidant and Antihyperlipidemic Status of Heliotropium zeylanicum Extract on Streptozotocin-Induced Diabetes in Rats
 
Creator Murugesh, Kandasamy
Yeligar, Veerendra
Dash, Deepak Kumar
Sengupta, Pinaki
Maiti, Bhim Chandra
Maity, Tapan Kumar
 
Subject Chemistry
 
Description The potential role of the methanolic extract of Heliotropium zeylanicum (BURM.F) LAMK (MEHZ) in the
treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin-induced diabetic rats. Oral administration of (MEHZ) 150 and 300 mg/kg/d for 14 d significantly decreased the
blood glucose level and considerably increased the body weight, food intake, and liquid intake of diabetic-induced
rats. MEHZ significantly decreased thiobarbituric acid reactive substances and significantly increased reduced
glutathione, superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 14 d of
treatment. The study also investigated the antihyperlipidemic potential of MEHZ. The results show that the active fraction of MEHZ is promising for development of a standardized phytomedicine for the treatment of diabetes
mellitus.
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/420/1/BIOLOGICAL_%26_PHARMACEUTICAL_BULLETIN%2C_29_(_11)%2C__2202%2D2205%2C_[18].pdf
Murugesh, Kandasamy and Yeligar, Veerendra and Dash, Deepak Kumar and Sengupta, Pinaki and Maiti, Bhim Chandra and Maity, Tapan Kumar (2006) Antidiabetic, Antioxidant and Antihyperlipidemic Status of Heliotropium zeylanicum Extract on Streptozotocin-Induced Diabetes in Rats. Biol. Pharm. Bull, 29 (11). pp. 2202-2205.
 
Relation htpp://dx.doi.org/10.1248/bpb.29.2202
http://www.eprints.iicb.res.in/420/