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Effect of sodium arsenite on peripheral lymphocytes in vitro: individual susceptibility among a population exposed to arsenic through the drinking water

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Title Effect of sodium arsenite on peripheral lymphocytes in vitro: individual
susceptibility among a population exposed to arsenic through the drinking water
 
Creator Mahata, Julie
Ghosh, Pritha
Sarkar, Jyotirindra N
Ray, Kunal
Natarajan, Adayapalam T
Giri, Ashok K
 
Subject Molecular & Human Genetics
 
Description Arsenic (As) contamination in ground water has affected
more than 19 countries. Approximately 36 million people
in the Bengal delta alone are exposed to this toxicant via
drinking water (>50 mg/l) and are at potential health risk.
Chronic ingestion of As via drinking water is associated
with occurrence of skin lesions, cancer and other arsenicinduced
diseases in West Bengal, India. An in vitro cytogenetic
study was performed utilizing chromosomal
aberrations (CA) in lymphocytes treated with sodium
arsenite (0±5 mM) in six symptomatic (having arsenicrelated
skin lesions) individuals, six age- and sex-matched
As-exposed asymptomatic (no arsenic-related skin lesions)
individuals and six control individuals with similar socioeconomic
status residing in non-affected districts of West
Bengal with no evidence of As exposure. The mean As content
in nails and hair was 9.61 and 5.23 mg/g in symptomatic,
3.48 and 2.17 mg/g in asymptomatic and 0.42 and
0.33 mg/g in the control individuals, respectively. The main
aim of our study was to determine whether genotoxic
effects differed in the lymphocytes of the control (no
exposure to arsenic), asymptomatic and symptomatic individuals
after in vitro treatment with sodium arsenite.
Although both the exposed groups had chronic exposure
to As through the drinking water, individuals with skin
lesions accumulated more As in their nails and hair and
excreted less in urine (127.80 versus 164.15 mg/l). The
results show that sodium arsenite induced a signiÆcantly
higher percentage of aberrant cells in the lymphocytes of
control individuals than in the lymphocytes of both the
exposed groups. Within the two exposed groups As
induced higher incidences of CA in the symptomatic than
the asymptomatic individuals. These results suggest that
asymptomatic individuals have relatively lower sensitivity
and susceptibility to induction of genetic damage by As
compared with the symptomatic individuals.
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/421/1/MUTAGENESIS%2C19(_3)%2C__223%2D229_[58].pdf
Mahata, Julie and Ghosh, Pritha and Sarkar, Jyotirindra N and Ray, Kunal and Natarajan, Adayapalam T and Giri, Ashok K (2004) Effect of sodium arsenite on peripheral lymphocytes in vitro: individual susceptibility among a population exposed to arsenic through the drinking water. Mutagenesis , 19 (3). pp. 223-229.
 
Relation http://dx.doi.org/10.1093/mutage/geh022
http://www.eprints.iicb.res.in/421/