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Melatonin protects against piroxicam-induced gastric ulceration

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Title Melatonin protects against piroxicam-induced gastric ulceration
 
Creator Bandyopadhyay, Debasish
Ghosh, Goutam
Bandyopadhyay, Arun
Reiter, Russel J
 
Subject Cell Biology & Physiology
 
Description The antiulcer e.ect of melatonin on gastric lesions caused by
piroxicam was studied with the intent of determining the mechanism of
action of this agent. Melatonin dose-dependently lowered piroxicam and
indomethacin-induced gastric damage with more than 90% inhibition at a
dose of 60 mg/kg BW. Increased lipid peroxidation, augmented protein
oxidation and decreased glutathione content of the gastric tissue following
piroxicam treatment indicated a possible involvement of oxidative stress in
this nonsteroidal anti-in.ammatory drug (NSAID)-induced gastropathy.
Pretreatment of rats with melatonin prevented these changes. Oral
administration of piroxicam to rats caused a threefold increase in the tissue
levels of hydroxyl radical generation, a change signi.cantly attenuated by
melatonin. Furthermore, a decrease in the activity of gastric peroxidase and
an increase in the activity of gastric superoxide dismutase(s) (SOD) because
of piroxicam treatment was attenuated by melatonin pretreatment indicating
that the indole possibly exerts its gastroprotective e.ects through its direct as
well as indirect antioxidant activities. The results of the present studies also
reveal that melatonin may in.uence the expression of Cu-Zn SOD, catalase,
cyclooxygenase as well as alpha-actinin whose levels were found to be
altered, following piroxicam treatment. The current studies, therefore,
document melatonin’s gastroprotective ability against piroxicam-induced
gastric damage and the .ndings raise the possibility of melatonin being
considered as a co-therapy with piroxicam or other NSAIDs in reducing the
gastropathy when long-term use of these nonsteroidal agents are
unavoidable.
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/427/1/JOURNAL_OF_PINEAL_RESEARCH%2C_36(_3)%2C_195%2D203_[67].pdf
Bandyopadhyay, Debasish and Ghosh, Goutam and Bandyopadhyay, Arun and Reiter, Russel J (2004) Melatonin protects against piroxicam-induced gastric ulceration. J. Pineal Res, 36 (3). pp. 195-203.
 
Relation http://dx.doi.org/10.1111/j.1600-079X.2004.00118.x
http://www.eprints.iicb.res.in/427/