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Topoisomerases of kinetoplastid parasites: why so fascinating

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Title Topoisomerases of kinetoplastid parasites:
why so fascinating
 
Creator Das, Benu Brata
Sengupta, Tanushri
Ganguly, Agneyo
Majumder, Hemanta K
 
Subject Infectious Diseases and Immunology
 
Description DNA topoisomerases are the key enzymes involved in
carrying out high precision DNA transactions inside
the cells. However, they are detrimental to the cell
when a wide variety of topoisomerase-targeted drugs
generate cytotoxic lesions by trapping the enzymes in
covalent complexes on the DNA. The discovery of
unusual heterodimeric topoisomerase I in kinetoplastid
family added a new twist in topoisomerase
research related to evolution, functional conservation
and their preferential sensitivity to Camptothecin. On
the other hand, structural and mechanistic studies on
kinetoplastid topoisomerase II delineate some distinguishing
features that differentiate the parasitic
enzyme from its prokaryotic and eukaryotic
counterparts. This review summarizes the recent
advances in research in kinetoplastid topoisomerases,
their evolutionary significance and the
death of the unicellular parasite Leishmania donovani
induced by topoisomerase I inhibitor camptothecin
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/432/1/MOLECULAR_MICROBIOLOGY%2C__62_(_4)%2C__917%2D927%2C2006_[17].pdf
Das, Benu Brata and Sengupta, Tanushri and Ganguly, Agneyo and Majumder, Hemanta K (2006) Topoisomerases of kinetoplastid parasites: why so fascinating. Molecular Microbiology, 62 (4). pp. 917-927.
 
Relation http://dx.doi.org/10.1111/j.1365-2958.2006.05428.x
http://www.eprints.iicb.res.in/432/