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Functional Delivery of a Cytosolic tRNA into Mutant Mitochondria of Human Cells

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Title Functional Delivery of a Cytosolic tRNA into Mutant Mitochondria of Human Cells
 
Creator Mahata, Bidesh
Mukherjee, Saikat
Mishra, Sumita
Bandyopadhyay, Arun
Adhya, Samit
 
Subject Molecular & Human Genetics
 
Description Many maternally inherited and incurable neuromyopathies are caused by mutations in mitochondrial
(mt) transfer RNA (tRNA) genes. Kinetoplastid protozoa, including Leishmania, have evolved specialized
systems for importing nucleus-encoded tRNAs into mitochondria. We found that the Leishmania RNA
import complex (RIC) could enter human cells by a caveolin-1–dependent pathway, where it induced
import of endogenous cytosolic tRNAs, including tRNALys, and restored mitochondrial function in a
cybrid harboring a mutant mt tRNALys (MT-TK) gene. The use of protein complexes to modulate
mitochondrial function may help in the management of such genetic disorders.
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/489/1/SCIENCE%2C_314(_5798)%2C_471%2D474_[24].pdf
Mahata, Bidesh and Mukherjee, Saikat and Mishra, Sumita and Bandyopadhyay, Arun and Adhya, Samit (2006) Functional Delivery of a Cytosolic tRNA into Mutant Mitochondria of Human Cells. Science, 314 (5798). pp. 471-474.
 
Relation http://dx.doi.org/10.1126/science.1130276
http://www.eprints.iicb.res.in/489/