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Micronuclei as Biomarkers of Carcinogen Exposure in Populations Exposed to Arsenic through Drinking Water in West Bengal, India: A Comparative Study in Three Cell Types

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Title Micronuclei as Biomarkers of Carcinogen Exposure
in Populations Exposed to Arsenic through
Drinking Water in West Bengal, India: A
Comparative Study in Three Cell Types
 
Creator Basu, Anamika
Ghosh, Pritha
Das, Jayanta K
Banerjee, Apurba
Ray, Kunal
Giri, Ashok K
 
Subject Molecular & Human Genetics
 
Description Contamination of groundwater by arsenic, a paradoxical
human carcinogen, has become a cause of global
public health concern. In West Bengal, India, the
groundwater in 9 of 18 districts is heavily contaminated
with arsenic. Various adverse health effects
including cancer have been reported from these
districts and are associated with prolonged arsenic
exposure. A cross-sectional biomarker study was
conducted to evaluate and compare the frequencies
of micronuclei in peripheral blood lymphocytes, oral
mucosa cells, and urothelial cells from the inhabitants
of North 24 Parganas, one of the arsenic-affected
districts. The three cell types were collected from 163
residents exposed to high levels of arsenic in drinking
water (214.7213 F 9.0273 Mg/l) and from 154 unexposed subjects residing in the unaffected East Midnapur
district with very little or no exposure to arsenic
through drinking water (9.2017 F 0.3157 Mg/l). Our
analysis revealed that micronuclei frequencies in the
exposed group were significantly elevated to 5.33-fold
over unexposed levels for lymphocytes, 4.63-fold for
oral mucosa cells, and 4.71-fold for urothelial cells
(increases in micronuclei frequencies significant at
P < 0.01). The results indicate that chronic ingestion of
arsenic in drinking water by the exposed subjects is
linked to the enhanced incidence of micronuclei in all
the three cell types, slightly higher level of micronuclei
being observed in lymphocytes compared with
oral mucosa and urothelial cells. (Cancer Epidemiol
Biomarkers Prev 2004;13(5):820–27)
 
Publisher American Association for Cancer Research
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/534/1/CANCER_EPIDEMIOLOGY_BIOMARKERS_%26_PREVENTION%2C_13(_5)%2C_820%2D827_[60].pdf
Basu, Anamika and Ghosh, Pritha and Das, Jayanta K and Banerjee, Apurba and Ray, Kunal and Giri, Ashok K (2004) Micronuclei as Biomarkers of Carcinogen Exposure in Populations Exposed to Arsenic through Drinking Water in West Bengal, India: A Comparative Study in Three Cell Types. Cancer Epidemiology Biomarkers & Prevention (CEBP), 13 (5). pp. 820-827. ISSN 1055-9965
 
Relation http://dx.doi.org/
http://www.eprints.iicb.res.in/534/