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Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of overexpressed disease-specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukaemia

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Title Increased interferon gamma production by peripheral blood
mononuclear cells in response to stimulation of overexpressed
disease-specific 9-O-acetylated sialoglycoconjugates in children
suffering from acute lymphoblastic leukaemia
 
Creator Ghosh, Shyamasree
Bandyopadhyay, Suman
Pal, Santanu
Das, Benubrata
Bhattacharya, Dilip K
Mandal, Chitra
 
Subject Infectious Diseases and Immunology
 
Description Disease-specific over-expression of 9-O-acetylated sialoglycoconjugates (9-OAcSGs)
on peripheral blood mononuclear cells (PBMC) of children with
acute lymphoblastic leukaemia (ALL, PBMCALL) has been demonstrated
using a lectin, Achatinin-H, with specificity towards 9-O-AcSAa2-6GalNAc.
This study investigated the contributory role of 9-O-AcSGs induced on
PBMCALL. Stimulation of PBMCALL with Achatinin-H through 9-O-AcSGs
led to a lymphoproliferative response with a significantly increased
interferon-c (IFN-c) production when compared with unstimulated cells as
demonstrated by enzyme-linked immunosorbent assay and mRNA
expression. Under identical conditions, PBMCALL ablated of O-acetylations
did not respond to such stimulation. In summary, it may be concluded that
stimulation of over-expressed 9-O-AcSGs regulate signalling for proliferation,
leading to the release of IFN-c. Controlled expression of these molecules may
be exploited as potential targets for therapy, promising beneficial effects to
children with ALL.
 
Publisher Blackwell Publishing
 
Date 2005
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/568/1/BRITISH_JOURNAL_OF_HAEMATOLOGY__128(_1)_35%2D41;2005[117].pdf
Ghosh, Shyamasree and Bandyopadhyay, Suman and Pal, Santanu and Das, Benubrata and Bhattacharya, Dilip K and Mandal, Chitra (2005) Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of overexpressed disease-specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukaemia. British Journal Of Haematology, 128 (1). pp. 35-41.
 
Relation http://dx.doi.org/10.1111/j.1365-2141.2004.05256.x
http://www.eprints.iicb.res.in/568/