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Infection of Human Mononuclear Phagocytes and Macrophage-Like THP1 Cells with Leishmania donovani Results in Modulation of Expression of a Subset of Chemokines and a Chemokine Receptor

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Title Infection of Human Mononuclear Phagocytes and
Macrophage-Like THP1 Cells with Leishmania
donovani Results in Modulation of Expression of a
Subset of Chemokines and a Chemokine Receptor
 
Creator Dasgupta, B
Roychoudhury, K
Ganguly, S
Akbar, M A
Das, P
Roy, Syamal
 
Subject Infectious Diseases and Immunology
 
Description The expression of chemokines and chemokine receptors was studied in
Leishmania donovani (LD)-infected human mononuclear phagocytes and the
human monocytic cell line THP1. Our studies showed that LD infection caused
the upregulation of three b chemokines (macrophage inflammatory protein-1
alpha (MIP-1a), MIP-1b and RANTES (regulated on activation normal T cell
expressed and secreted)), one a chemokine (interleukin-8 (IL-8)) and the CC
chemokine receptor 5 (CCR5) but not CCR1, as evident from reverse transcriptase-
polymerase chain reaction (RT-PCR) analysis. The CCR5 upregulation
in human mononuclear phagocytes and THP1 cells was also evident by
confocal microscopy. The possible association of such upregulation in relation to
Leishmania and human immunodeficiency virus (HIV) coinfection was discussed
 
Publisher Blackwell Publishing
 
Date 2003
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/616/1/SCANDINAVIAN_JOURNAL_OF_IMMUNOLOGY%2C_57(_4)%2C366%2D374[70].pdf
Dasgupta, B and Roychoudhury, K and Ganguly, S and Akbar, M A and Das, P and Roy, Syamal (2003) Infection of Human Mononuclear Phagocytes and Macrophage-Like THP1 Cells with Leishmania donovani Results in Modulation of Expression of a Subset of Chemokines and a Chemokine Receptor. Scandinavian Journal Of Immunology, 57 (4). pp. 366-374.
 
Relation http://dx.doi.org/10.1046/j.1365-3083.2003.01227.x
http://www.eprints.iicb.res.in/616/