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Synthesis of Enantiomerically Pure Nucleosides and Analogues Involving Carbohydrates as Chiral Pool

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Title Synthesis of Enantiomerically Pure Nucleosides and Analogues Involving Carbohydrates as Chiral Pool
 
Creator Roy, Biswajit Gopal
 
Subject Chemistry
 
Description The area of carbocyclic nucleosides has developed after the isolation of (-)-aristeromycin (1) and
(-)-neplanocin A (2) from natural sources showing antileukemic activity. Many of the carbocyclic
nucleosides, arising from the replacement of the furanose ring oxygen by a carbon atom, exhibit
interesting antiviral properties against herpes simplex virus (HSV 1 and 2), human cytomegalovirus,
hepatitis B virus and human immunodeficiency virus (HIV). One of the reasons for the remarkable
activities of this class of nucleosides is their better chemical as well as metabolic stability against
various chemicals and enzymes. Among various analogues, carbovir (3), and abacavir (4),
carboxetanocin G (5), (-)-BCA (6), BVDU (7) and carba-2/-ara-fluoroguanosine (8) show important
biological properties. Carbocyclic nucleosides containing cyclohexenyl, cyclohexyl (9 and 10), and
cyclopropyl (11 and 12) analogues have also been reported to be potential inhibitors of HIV, cancer
and viruses
 
Date 2007
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/625/1/Thesis%2D_BIswajit_Gopal_Roy.pdf
Roy, Biswajit Gopal (2007) Synthesis of Enantiomerically Pure Nucleosides and Analogues Involving Carbohydrates as Chiral Pool. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/625/