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Negligible Male Gene Flow Across Ethnic Boundaries in India, Revealed by Analysis of Y-Chromosomal DNA Polymorphisms

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Title Negligible Male Gene Flow Across Ethnic
Boundaries in India, Revealed by Analysis
of Y-Chromosomal DNA Polymorphisms
 
Creator Bhattacharyya, Nitai Pada
Basu, Priyadarshi
Das, Madhusudan
Pramanik, Srimanta
Banerjee, Rajat
Roy, Bidyut
Roychoudhury, Susanta
Majumder, Partha P
 
Subject Molecular & Human Genetics
 
Description From the historically prevalent social structure of Indian populations it may be predicted that there has been
very little male gene flow across ethnic boundaries. To test this finding, we have analyzed DNA samples of
individuals belonging to 10 ethnic groups, speaking Indo-European or Austroasiatic languages and inhabiting the
eastern and northern regions of India. Eight Y-chromosomal markers, two biallelic and six microsatellite, were
studied. All populations were monomorphic for the deletion allele at the YAP (DYS287) locus and for the 119-bp
allele at the DYS288 locus. Y-chromosomal haplotypes were constructed on the basis of one RFLP locus and five
microsatellite loci. The haplotype distribution among the groups showed that different ethnic groups harbor
nearly disjoint sets of haplotypes. This indicates that there has been virtually no male gene flow among ethnic
groups. Analysis of molecular variance revealed that there was significant haplotypic variation between castes
and tribes, but nonsignificant variation among ranked caste clusters. Haplotypic variation attributable to
differences in geographical regions of habitat was also nonsignificant.
 
Date 1999
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/668/1/GENOME_RESEARCH__9(_8)711%2D719;1999[31].pdf
Bhattacharyya, Nitai Pada and Basu, Priyadarshi and Das, Madhusudan and Pramanik, Srimanta and Banerjee, Rajat and Roy, Bidyut and Roychoudhury, Susanta and Majumder, Partha P (1999) Negligible Male Gene Flow Across Ethnic Boundaries in India, Revealed by Analysis of Y-Chromosomal DNA Polymorphisms. Genome Research , 9 (8). pp. 711-719.
 
Relation http://dx.doi.org/
http://www.eprints.iicb.res.in/668/