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Role of carcinoscorpin, a haemolymph lectin of horseshoe crab Carcinoscorpius rotundacauda as humoral factor

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Title Role of carcinoscorpin, a haemolymph lectin of horseshoe crab
Carcinoscorpius rotundacauda as humoral factor
 
Creator Basu Sarbadhikari, S
Datta, D
Bhadra, R
 
Subject Infectious Diseases and Immunology
 
Description This study demonstrated that a marine Indian horseshoe crab, Carcinoscorpious rotundacauda showed higher
self defence in an experimental infection upon the induction of its circulatory lectin, carcinoscorpin. It resisted an
infection with 10 7 live Escherichia coli per crab when the circulatory carcinoscorpin was 8-16-fold higher after
administering 2-ketodeoxyoctonate (Kdo) into the live crab. The naive control with its natural level of circulatory
lectin could tolerate a maximum infective dose of 106 live E. coli per crab. Bacterial kiliing and phagocytic
uptake in association with the isolated crab amoebocytes in an ex vivo system was considerably higher for the
lectin opsonized E. coli compared to unopsonized samples. Carcinoscorpin is thus functionally an opsonin in the
defence of the primitive marine arthropod, C. rotundacauda, like vertebrate antibody, a humoral factor involved
in the defence of the host. The natural capacity for defending an infection with 106 live E. coli per crab suggested
that the crabs in the natural habitat hardly face such an infection and is possibly one of the reasons for its survival
over millions of years as a living Ibssil.
 
Date 1999
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/678/1/JOURNAL_OF_BACTERIOLOGY__181(_3)_879%2D883;1999[78].pdf
Basu Sarbadhikari, S and Datta, D and Bhadra, R (1999) Role of carcinoscorpin, a haemolymph lectin of horseshoe crab Carcinoscorpius rotundacauda as humoral factor. Journal of Biosciences, 24 (4). pp. 471-476.
 
Relation http://dx.doi.org/
http://www.eprints.iicb.res.in/678/