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Hepatotoxicity of Diazepam Structural and Trace Metal Studies in Rat

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Title Hepatotoxicity of Diazepam
Structural and Trace Metal Studies in Rat
 
Creator Chatterjee, sunil
Chatterjee, Jyotirmoy
Chaudhuri, Keya
Basu, Shyamal
Maiti, Chitta
 
Subject Molecular & Human Genetics
 
Description Studies of effects of diazepam on liver parenchyma are very
scanty. In this study, adult albino rats were treated with diazepam in
two different doses (0.25 mg and 0.30 mg/kg body wt) daily for 30
and 60 d. Through light microscopy and electron microscopy,
prenecrotic and necrotic changes were noted in the high-dose group.
Trace metal analysis indicated that zinc (Zn) was reduced by 30 and
60 day under both the doses, whereas iron (Fe) and copper (Cu) were
reduced significantly in these groups only after 60 d of treatment.
This reduction in metal contents may have some correlations with
necrotic changes in liver parenchyma.
 
Date 1997
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/728/1/BIOLOGICAL_TRACE_ELEMENT_RESEARCH%2C_57(_3)%2C_239%2D250[52].pdf
Chatterjee, sunil and Chatterjee, Jyotirmoy and Chaudhuri, Keya and Basu, Shyamal and Maiti, Chitta (1997) Hepatotoxicity of Diazepam Structural and Trace Metal Studies in Rat. Biological Trace Element Research, 57 (3). pp. 239-250.
 
Relation http://dx.doi.org/10.1007/BF02785292
http://www.eprints.iicb.res.in/728/