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Leishmania donovani Parasites Interact with g/dþ Human Peripheral Blood T Cells and Induce Susceptibility to NK Cell-Mediated Lysis

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Title Leishmania donovani Parasites Interact with g/dþ Human Peripheral
Blood T Cells and Induce Susceptibility to NK Cell-Mediated Lysis
 
Creator Saha, A
Charkrabarti, G
Bandyopadhyay, Santu
 
Subject Infectious Diseases and Immunology
 
Description We recently reported that Leishmania donovani infect the human T-cell line in vitro. To examine whether
primary human T cells could be infected by this parasite, a direct interaction of the peripheral blood T cells
with L. donovani was examined. The percentage of g/dþ T cells was markedly increased when in vitro
generated normal human T-cell blasts were cultured with L. donovani amastigotes. About 30% of the g/dþ T
cells in the parasite exposed T-cell blasts expressed parasite antigens intracellularly without detectable
intracellular parasites. Parasite exposed T-cell blasts had a reduced surface expression of HLA-DR and were
lysed by the sorted CD56þ cells. In contrast, neither L. donovani amastigotes nor T-cell blasts exposed to heat
killed amastigotes and/or were sensitive to the NK cell-mediated lysis. Of interest is that about 10% CD3þ
peripheral blood T cells in two out of three Indian Kala-azar patients tested expressed intracellular L. donovani
antigens
 
Publisher Blackwell Publishing
 
Date 1999
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/729/1/SCANDINAVIAN_JOURNAL_OF_IMMUNOLOGY__50_(_6_)_588%2D595;1999[3].pdf
Saha, A and Charkrabarti, G and Bandyopadhyay, Santu (1999) Leishmania donovani Parasites Interact with g/dþ Human Peripheral Blood T Cells and Induce Susceptibility to NK Cell-Mediated Lysis. Scandinavian Journal Of Immunology, 50 (6). pp. 588-595.
 
Relation http://dx.doi.org/
http://www.eprints.iicb.res.in/729/