ICAR Research Data Repository for Knowledge Management
Amarogentin, a Naturally Occurring Secoiridoid Glycoside and a Newly Recognized Inhibitor of Topoisomerase I from Leishmania donouani
EPrints@IICB
View Archive Info| Field | Value | |
| Title |
Amarogentin, a Naturally Occurring Secoiridoid Glycoside and a Newly Recognized Inhibitor of Topoisomerase I from Leishmania donouani |
|
| Creator |
Ray, Sutapa
Majumder, Hemanta K Chakravarty, Ajit K Mukhopadhyay, Sibabrata |
|
| Subject |
Chemistry
|
|
| Description |
A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides: amarogentin (11, amaroswerin (21, and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation. |
|
| Date |
1996
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/739/1/JOURNAL_OF_NATURAL_PRODUCTS%2C_59(_1)%2C_27%2D29%2C_DOI_10.1021np960018g%2C1996_[67].pdf
Ray, Sutapa and Majumder, Hemanta K and Chakravarty, Ajit K and Mukhopadhyay, Sibabrata (1996) Amarogentin, a Naturally Occurring Secoiridoid Glycoside and a Newly Recognized Inhibitor of Topoisomerase I from Leishmania donouani. Journal of Natural Products, 59 (1). pp. 27-29. |
|
| Relation |
http://www.eprints.iicb.res.in/739/
|
|