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Amarogentin, a Naturally Occurring Secoiridoid Glycoside and a Newly Recognized Inhibitor of Topoisomerase I from Leishmania donouani

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Title Amarogentin, a Naturally Occurring Secoiridoid Glycoside and a Newly
Recognized Inhibitor of Topoisomerase I from Leishmania donouani
 
Creator Ray, Sutapa
Majumder, Hemanta K
Chakravarty, Ajit K
Mukhopadhyay, Sibabrata
 
Subject Chemistry
 
Description A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of
Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides:
amarogentin (11, amaroswerin (21, and sweroside (3). Amarogentin is a potent inhibitor of
type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme,
preventing binary complex formation.
 
Date 1996
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/739/1/JOURNAL_OF_NATURAL_PRODUCTS%2C_59(_1)%2C_27%2D29%2C_DOI_10.1021np960018g%2C1996_[67].pdf
Ray, Sutapa and Majumder, Hemanta K and Chakravarty, Ajit K and Mukhopadhyay, Sibabrata (1996) Amarogentin, a Naturally Occurring Secoiridoid Glycoside and a Newly Recognized Inhibitor of Topoisomerase I from Leishmania donouani. Journal of Natural Products, 59 (1). pp. 27-29.
 
Relation http://www.eprints.iicb.res.in/739/