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Nitric Oxide:An Antioxidant and Neuroprotector

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Title Nitric Oxide:An Antioxidant and Neuroprotector
 
Creator Mohanakumar, K P
Thomas, Bobby
Sharma N, Sudarshan
Muralikrishnan, Dhanasekharan
Chowdhury, Rukhsana
Chiueh, Chuang C
 
Subject Cell Biology & Physiology
 
Description Indirect evidence, including neuroprotection against 1-methyl-4-
phenyl-1,2,3,6-tetrahydropyridine (MPTP)-neurotoxicity by nitric oxide synthase
(NOS) inhibitors and resistance of transgenic animals deficient in NOS,
is controversial. We have reviewed evidence in favor of oxidative stress during
the development of MPTP-neurotoxicity and the influence of antioxidants,
including nitric oxide (NO) and NO donors, on MPTP-induced dopaminergic
neurotoxicity. Systemic administration of MPTP causes dose-dependent generation
of hydroxyl radicals (OH)
in vivo
in the striatum in mice; OH scavengers
protect dopaminergic neurons from this insult. On the other hand the role
of NO in MPTP-neurotoxicity is controversial. Hitherto, no direct evidence for
the involvement of NO in MPTP neurotoxicity has been available. MPTP does
not affect inducible-NOS mRNA level or its expression in SN or the striatum.
Nitroglycerine, a NO donor, can attenuate MPTP-induced dopamine depletion
in the striatum by virtue of its OH scavenging action. Several other NO donors
have also been shown to scavenge the OH generated, following Fenton chemistry
in vitro
, and to protect against
in vivo
dopaminergic neurotoxicity by small
mass iron complex formation. This evidence suggests that NO renders protection
against MPTP-induced OH-mediated nigrostriatal lesions, acting as an
antioxidant.
 
Date 2002
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/743/1/ANNALS_OF_THE_NEW_YORK_ACADEMY_OF_SCIENCES__962%2C_389%2D401;2002[72].pdf
Mohanakumar, K P and Thomas, Bobby and Sharma N, Sudarshan and Muralikrishnan, Dhanasekharan and Chowdhury, Rukhsana and Chiueh, Chuang C (2002) Nitric Oxide:An Antioxidant and Neuroprotector. Annals of the New York Academy of Sciences, 962. pp. 389-401.
 
Relation http://dx.doi.org/
http://www.eprints.iicb.res.in/743/