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Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters

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Title Combination Therapy with Indolylquinoline Derivative and
Sodium Antimony Gluconate Cures Established Visceral
Leishmaniasis in Hamsters
 
Creator Pal, Chiranjib
Raha, Mousumi
Basu, Anirban
Roy, Keshab Chandra
Gupta, Anasuya
Ghosh, Monidipa
Sahu, N P
Banerjee, Sukdeb
Mondal, Nirup B
Bandyopadhyay, Santu
 
Subject Chemistry
Infectious Diseases and Immunology
 
Description 2-(2�-Dichloroacetamidobenzyl)-3-(3�-indolylquinoline), designated indolylquinoline derivative A, reduced
the splenic and the liver parasite burdens by >93.0% in Leishmania donovani-infected hamsters, whereas
sodium antimony gluconate (SAG) reduced the burdens approximately 80.0%. Complete clearance of parasitemia
from the livers and spleens was noticed when infected animals received indolylquinoline derivative A
plus SAG, suggesting that indolylquinoline derivative A has potential as a new agent for sole or conjunctive
therapy for leishmaniasis.
 
Publisher American Society for Microbiology
 
Date 2002
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/744/1/ANTIMICROBIAL_AGENTS_AND_CHEMOTHERAPY_46(_1)_259%2D2612002[75].pdf
Pal, Chiranjib and Raha, Mousumi and Basu, Anirban and Roy, Keshab Chandra and Gupta, Anasuya and Ghosh, Monidipa and Sahu, N P and Banerjee, Sukdeb and Mondal, Nirup B and Bandyopadhyay, Santu (2002) Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters. Antimicrobial Agents and Chemotherapy, 46 (1). pp. 259-261.
 
Relation http://dx.doi.org/10.1128/AAC.46.1.259-261.2002
http://www.eprints.iicb.res.in/744/