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Synthesis of a Novel Quinoline Derivative, 2-(2-Methylquinolin-4- ylamino)-N-phenylacetamide—A Potential Antileishmanial Agent

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Title Synthesis of a Novel Quinoline Derivative, 2-(2-Methylquinolin-4-
ylamino)-N-phenylacetamide—A Potential Antileishmanial Agent
 
Creator Sahu, Niranjan P
Pal, Chiranjib
Mondal, Nirup B
Banerjee, Sukdeb
Raha, Mausumi
Kundu, Ashis P
Basu, Anirban
Ghosh, Monidipa
Roy, Keshab
Bandyopadhyay, Santu
 
Subject Chemistry
Infectious Diseases and Immunology
 
Description Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)-
N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate
(SAG) in reducing the parasite load both in the spleen and liver at a much lower concentration in hamster models. The results
suggest that the compound could be exploited as an antileishmanial drug. # 2002 Elsevier Science Ltd. All rights reserved.
 
Publisher Elsevier
 
Date 2002
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/748/1/BIOORGANIC_%26_MEDICINAL_CHEMISTRY_10_(_6)_1687%2D1693;2002[54].pdf
Sahu, Niranjan P and Pal, Chiranjib and Mondal, Nirup B and Banerjee, Sukdeb and Raha, Mausumi and Kundu, Ashis P and Basu, Anirban and Ghosh, Monidipa and Roy, Keshab and Bandyopadhyay, Santu (2002) Synthesis of a Novel Quinoline Derivative, 2-(2-Methylquinolin-4- ylamino)-N-phenylacetamide—A Potential Antileishmanial Agent. Bioorganic & Medicinal Chemistry, 10 (6). pp. 1687-1693.
 
Relation http://dx.doi.org/10.1016/S0968-0896(02)00046-9
http://www.eprints.iicb.res.in/748/