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Studies on Stibanate unresponsive isolates of Leishmania donovani

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Title Studies on Stibanate unresponsive isolates of Leishmania donovani
 
Creator Bhattacharyya, Anindita
Mukherjee, Mandira
Duttagupta, Swadesh
 
Subject Structural Biology & Bioinformatics
 
Description Visceral leishmaniasis, also known as kala-azar (KA) is generally caused by Leishmania donovani. Organic
pentavalent antimonials (SbV) is the first line of treatment for KA. However, the number of KA patients unresponsive
to treatment with Sb(V) is steadily increasing in India and elsewhere. The primary objective of this
work is to determine the factor(s) associated with the rise of unresponsiveness. Analysis of the clonal population
of parasites clearly indicated that wild type parasites isolated from KA patients who were clinically cured after
treatment with Sb(V), were a mixture of resistant and sensitive cells. The resistant promastigotes were also
resistant as amastigotes in vivo. It was further observed that Stibanate sensitive parasites can be made resistant
to the drug by repeated passages in experimental animals followed by incomplete treatment with suboptimal
doses of the drug. These results suggest that the steady rise in Sb(V) unresponsiveness of KA patients in India is
due to infection with resistant parasites, generated as a result of irregular and often incomplete treatment of the
patients.
 
Date 2002
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/761/1/JOURNAL_OF_BIOSCIENCES_27(_5)_503%2D508;2002[28].pdf
Bhattacharyya, Anindita and Mukherjee, Mandira and Duttagupta, Swadesh (2002) Studies on Stibanate unresponsive isolates of Leishmania donovani. Journal of Biosciences, 27 (5). pp. 503-508.
 
Relation http://dx.doi.org/10.1007/BF02705047
http://www.eprints.iicb.res.in/761/