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Antidiarrhoeal Activity of Seed Extract of Albizzia lebbeck Benth.

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Title Antidiarrhoeal Activity of Seed Extract of
Albizzia lebbeck Benth.
 
Creator Besra, S E
Gomes, Aparna
Chaudhury, L
Vedasiromoni, J R
Ganguly, D K
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description The antidiarrhoeal activity of the seed extract of Albizzia lebbeck (Benth.) was investigated employing
conventional rodent models of diarrhoea, i.e. castor oil-induced diarrhoea, upper gastrointestinal transit
(u.g.t.) and fluid secretion. It was found that the aqueous methanol extract of Albizzia lebbeck seeds (2.5–
5 mg/kg i.p.) possessed antidiarrhoeal activity which strengthens the earlier use of the seeds in the treatment
of diarrhoea and dysentery. The antidiarrhoeal dose of the extract was at least 10–30 times less
than the LD50 dose. The extract (2.5–5 mg/kg i.p.) potentiated the antidiarrhoeal activity of loperamide
(1 mg/kg i.p.). Nalaxone (0.5 mg/kg i.p.) significantly inhibited the antidiarrhoeal activity of the extract as
well as loperamide, thus indicating a role of the opioid system in the antidiarrhoeal activity of the
extract.
 
Publisher John Wiley & Sons
 
Date 2002
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/786/1/PHYTOTHERAPY_RESEARCH__16(_6)_529%2D533;2002[31].pdf
Besra, S E and Gomes, Aparna and Chaudhury, L and Vedasiromoni, J R and Ganguly, D K (2002) Antidiarrhoeal Activity of Seed Extract of Albizzia lebbeck Benth. Phytotherapy Research, 16 (6). pp. 529-533. ISSN 0951-418X
 
Relation http://dx.doi.org/10.1002/ptr.961
http://www.eprints.iicb.res.in/786/