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Antileishmanial Activities of Stearylamine-Bearing Liposomes

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Title Antileishmanial Activities of Stearylamine-Bearing Liposomes
 
Creator Dey, Tuhina
Anam, Khairul
Afrin, Farhat
Ali, Nahid
 
Subject Infectious Diseases and Immunology
 
Description Here we report the activity of liposomes comprising egg phosphatidylcholine (PC) and stearylamine (SA)
against Leishmania donovani parasites. Both promastigotes and intracellular amastigotes in vitro and in vivo
were susceptible to SA-PC liposomes. A single dose of 55 mg of SA-PC liposomes/animal could significantly
reduce the hepatic parasite burden by 85 and 68% against recent and established experimental visceral
leishmaniasis, respectively, suggesting their strong therapeutic potential.
 
Publisher American Society for Microbiology
 
Date 2000
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/800/1/ANTIMICROBIAL_AGENTS_AND_CHEMOTHERAPY__44(6)1739%2D1742;2000[37].pdf
Dey, Tuhina and Anam, Khairul and Afrin, Farhat and Ali, Nahid (2000) Antileishmanial Activities of Stearylamine-Bearing Liposomes. Antimicrobial Agents and Chemotherapy, 44 (6). pp. 1739-1742.
 
Relation http://dx.doi.org/10.1128/AAC.44.6.1739-1742.2000
http://www.eprints.iicb.res.in/800/