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Altered Membrane Permeability as the Basis of Bactericidal Action of Methdilazine

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Field Value
 
Title Altered Membrane Permeability as the Basis of Bactericidal Action of Methdilazine
 
Creator Chattopadhyaya, Debprasad
Mukherjee, Tanmoy
Pal, Prajnamoy
Saha, Bhaskar
Bhadra, Ranjan
 
Subject Chemistry
 
Description The growth inhibition of Escherichia coli and Staphylococcus aureus was accompanied by
significant release of K+ and UV-absorbing small molecules upon exposure to methdilazine, an extensively used phenothiazine antihistamine. A severe decrease in [U-14 glucose uptake and a rapid efflux of hexose from sugar-preloaded bacteria were also observed but without
visible cellular lysis. Considerable damage to membrane permeability by methdilazine was proposed to explain the rapid loss in cfu/mL of the bacteria.
 
Date 1998
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/847/1/JOURNAL_OF_ANTIMICROBIAL_CHEMOTHERAPY%2C__42(_1)%2C_83%2D86[31].pdf
Chattopadhyaya, Debprasad and Mukherjee, Tanmoy and Pal, Prajnamoy and Saha, Bhaskar and Bhadra, Ranjan (1998) Altered Membrane Permeability as the Basis of Bactericidal Action of Methdilazine. Journal of Antimicrobial Chemotherapy, 42 (1). pp. 83-86.
 
Relation http://dx.doi.org/10.1093/jac/42.1.83
http://www.eprints.iicb.res.in/847/