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Avirulent mutants of Macrophomina phaseolina and Aspergillus fumigatus initiate infection in Phaseolus mungo in the presence of phaseolinone;levamisole gives protection

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Title Avirulent mutants of Macrophomina phaseolina and Aspergillus fumigatus initiate infection in Phaseolus mungo in the presence of phaseolinone;levamisole gives protection
 
Creator Sett, Suchandra
Mishra, Sontosh K
Siddique, K A I
 
Subject Infectious Diseases and Immunology
 
Description To evaluate the role of phaseolinone, a phytotoxin produced by Macrophomina phaseolina, in disease initiation,
three nontoxigenic avirulent mutants of the fungus were generated by UV-mutagenesis. Two of them were able to initiate
infection in germinating Phaseolus mungo seeds only in the presence of phaseolinone. The minimum dose of
phaseolinone required for infection in 30% seedlings was 2·5 μg/ml. A human pathogen, Aspergillus fumigatus was
also able to infect germinating seeds of P. mungo in the presence of 5 μg/ml concentration of phaseolinone. Phaseolinone
seemed to facilitate infection by A. fumigatus, which is not normally phytopathogenic, by reducing the immunity
of germinating seedlings in a nonspecific way. Levamisole, a non-specific immunopotentiator gave protection
against infection induced by A. fumigatus at an optimum dose of 50 μg/ml. Sodium malonate prevented the effects of
levamisole.
 
Date 2000
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/858/1/JOURNAL_OF_BIOSCIENCES__25_(1)73%2D80;2000[56].pdf
Sett, Suchandra and Mishra, Sontosh K and Siddique, K A I (2000) Avirulent mutants of Macrophomina phaseolina and Aspergillus fumigatus initiate infection in Phaseolus mungo in the presence of phaseolinone;levamisole gives protection. Journal of Bioscieces, 25 (1). pp. 73-80.
 
Relation http://dx.doi.org/10.1007/BF02985184
http://www.eprints.iicb.res.in/858/