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Studies on the Genesis of Vibrio cholerae 01 39: Identification of Probable Progenitor Strains

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Title Studies on the Genesis of Vibrio cholerae 01 39:
Identification of Probable Progenitor Strains
 
Creator Pajni, Sangeeta
Sharma, Charu
Bhasin, Navneet
Ghosh, Amit
Ramamurthy, T
Nair, G. Balakrish
Das, Blswajlt
Kar , Sudeshna
Roychowdhury , Saumya
Ghosh, R K
 
Subject Infectious Diseases and Immunology
 
Description Four lines of evidence suggest that the recent outbreak strains of Vibrio cholerae
0139 could have emerged from serogroup 0 1 strains typified by isolates MOl and M0477
described in this paper, which are neither truly classical nor truly El Tor in their biotype
attributes. Firstly, like all 0139 isolates, these 0 1 strains, isolated in Madras during and
before the 0139 outbreak, were resistant not only to polymyxin B but also to all biotypespecific
choleraphages, i.e. classical phage (Dl49 and El Tor phages e4 and e5. Secondly, the
restriction fragment pattern (RFP) polymorphism displayed by these strains for the cholera
toxin (ctx) gene, were identical with those produced by 0139 isolates but were different from
those of 0 1 type strains, namely V. cholerae 569B (classical) and V. cholerae MAK757 (El
Tor). Thirdly, all the 0139 isolates and the two 0 1 isolates carried an identical large number
of copies of cholera toxin gene in their chromosomes. Finally, the outer-membrane protein
profiles of strains MO 1 and M0477 were identical to those of 0 139 isolates but were different
from those displayed by strains 569B and MAK757.
 
Publisher Society for General Microbiology
 
Date 1995
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/899/1/JOURNAL_OF_MEDICAL_MICROBIOLOGY___42(1)20%2D25;1995[61].pdf
Pajni, Sangeeta and Sharma, Charu and Bhasin, Navneet and Ghosh, Amit and Ramamurthy, T and Nair, G. Balakrish and Das, Blswajlt and Kar , Sudeshna and Roychowdhury , Saumya and Ghosh, R K (1995) Studies on the Genesis of Vibrio cholerae 01 39: Identification of Probable Progenitor Strains. Journal of Medical Microbiology, 42 (1). pp. 20-25. ISSN 0022-2615
 
Relation http://dx.doi.org/10.1099/00222615-42-1-20
http://www.eprints.iicb.res.in/899/