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Oxidative damage of erythrocytes: a possible mechanism for premature hemolysis in experimental visceral leishmaniasis in hamsters

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Title Oxidative damage of erythrocytes: a possible mechanism
for premature hemolysis in experimental visceral leishmaniasis in hamsters
 
Creator Sen, G
Mukhopadhyay, Ranjan
Ghosal, J
Biswas, Tuli
 
Subject Cell Biology & Physiology
 
Description Visceral leishmaniasis is accompanied by severe
anemia and pancytopenia. Reactive oxygen species
are known to contribute to the pathogenesis of several
red blood cell (RBCs) disorders. The present study
reveals the extent of oxidative stress and the efficacy of
the primary antioxidant system in erythrocytes of hamsters
in the progressive anemic response at different
stages of leishmanial infection. Increased intracellular
precipitation of Heinz bodies secondary to oxidative
denaturation of hemoglobin and enhanced formation
of malonyldialdehyde suggest oxidative damage of erythrocytes,
both in the hemoglobin and cell membrane,
respectively. Decreased activities of superoxide dismutase
and catalase in the infected animals indicate the
generation of O2
0 – and H2O2, which in turn may produce
the highly reactive 0OH species. Decreases in the
reduced glutathione level along with the decreased activities of glutathione reductase and glutathione peroxidase point to a deficient antioxidant defense system
during the post-infection period. Accentuated degradation
of both cytoskeletal and integral membrane proteins
after 3 months of infection may eventually lead to
membrane destabilization and early lysis of erythrocytes
in experimental visceral leishmaniasis.
 
Date 2001
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/919/1/ANNALS_OF_HEMATOLOGY%2C_80(_1)%2C_32%2D37%2C2001[64].pdf
Sen, G and Mukhopadhyay, Ranjan and Ghosal, J and Biswas, Tuli (2001) Oxidative damage of erythrocytes: a possible mechanism for premature hemolysis in experimental visceral leishmaniasis in hamsters. Annals of Hematology, 80 (1). pp. 32-37.
 
Relation http://dx.doi.org/10.1007/s002770000240
http://www.eprints.iicb.res.in/919/