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Sialoglycans in protozoal diseases: Their detection, modes of acquisition and emerging biological roles

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Title Sialoglycans in protozoal diseases: Their detection,
modes of acquisition and emerging biological roles
 
Creator Chava, Anil Kumar
Bandyopadhyay, Sumi
Chatterjee, Mitali
Mandal, Chitra
 
Subject Cancer Biology and Inflammatory Disorder Division
 
Description Protozoan parasites including Plasmodia, Leishmania, Trypanosoma, Entamoeba, Trichomonas and others cause diseases
in humans and domestic livestock having far-reaching socio-economic implications. They show remarkable propensity
to survive within hostile environments encountered during their life cycle, and the identification of molecules that enable
them to survive in such milieu is a subject of intense research. Currently available knowledge of the parasite cell surface
architecture and biochemistry indicates that sialic acid and its principle derivatives are major components of the glycocalyx and assist the parasite to interact with its external environment through functions ranging from parasite survival, infectivity and host-cell recognition. This review highlights the present state of knowledge with regard to parasite sialobiology with an emphasis on its mode(s) of acquisition and their emerging biological roles, notably as an anti-recognition molecule thereby aiding the pathogen to evade host defense mechanisms.
 
Date 2003
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/929/1/GLYCOCONJUGATE_JOURNAL%2C__20(_3)%2C_199%2D206[91].pdf
Chava, Anil Kumar and Bandyopadhyay, Sumi and Chatterjee, Mitali and Mandal, Chitra (2003) Sialoglycans in protozoal diseases: Their detection, modes of acquisition and emerging biological roles. Glycoconjugate Journal, 20 (3). pp. 199-206.
 
Relation http://dx.doi.org/10.1023/B:GLYC.0000024251.30100.08
http://www.eprints.iicb.res.in/929/