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A Phaseolinone new Antileishmanial Compound.

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Title A Phaseolinone new Antileishmanial Compound.
 
Creator Roy, Rabindra
Bhattacharyya, Gautam
Siddique, K A I
Bhadra, Ranjan
 
Subject Infectious Diseases and Immunology
 
Description Inclusion of phaseolinone, a newly described mycotoxin, at
20 pg’ per ml in a solid culture medium (blood agar overlay) and at 5Opg
per ml in a liquid culture (medium 199) inhibited the growth of L. -d.o novani
promastigotes. About 90% of the motile promastigotes lost -motility
after exposure to 50 pg per ml of phaseolinone for 6-7 h and here 3-
day-old culture was more sensitive than 7-day-old culture. In an in vitro
assay, DNA dependent RNA polymerase activity of 3-day-old promazis
was considerably inhibited in the presence of this toxin. Therefore,
this key enzyme was suggested to be one of the sites of action of phaseolinone.
 
Publisher Elsevier
 
Date 1990
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/939/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS_168_(1)_51%2D57;1990[46].pdf
Roy, Rabindra and Bhattacharyya, Gautam and Siddique, K A I and Bhadra, Ranjan (1990) A Phaseolinone new Antileishmanial Compound. Biochemical and Biophysical Research Communications, 168 (1). pp. 43-50.
 
Relation http://dx.doi.org/10.1016/0006-291X(90)91672-F
http://www.eprints.iicb.res.in/939/