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Phasjzolinone, a new Mycotoxin, Inhibits RNA Polyyerase(s) other Than rna Polymerase II

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Title Phasjzolinone, a new Mycotoxin, Inhibits RNA Polyyerase(s)
other Than rna Polymerase II
 
Creator Bhattacharyya, Goutam
Roy, Amit
Siddique, K A I
Bhadra, Ranjan
 
Subject Infectious Diseases and Immunology
 
Description DNA-dependent RNA synthesis in an isolated rat liver nuclei -i n
vitro assay was inhibited by 41 and 61% in the presence of ff-amanitin,
the inhibitor specific for RNA polymerase II and phaseolinone, a new
mycotoxin, respectively. This inhibition reached 97% when these two
inhibitors were present together. The RNA polymerase activity present
in a nucleolar fraction was inhibited by greater than 80% in presence
of phaseolinone, but phaseolinone and DNA showed no interaction as judged
from CD spectra or density gradient centrifugation of toxin-treated DNA.
This evidence suggested that phaseolinone inhibited RNA polymerase activity
other than RNA polymerase II.
 
Publisher Elsevier
 
Date 1990
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/947/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS_168_(1)_51%2D57;1990[46].pdf
Bhattacharyya, Goutam and Roy, Amit and Siddique, K A I and Bhadra, Ranjan (1990) Phasjzolinone, a new Mycotoxin, Inhibits RNA Polyyerase(s) other Than rna Polymerase II. Biochemical and Biophysical Research Communications, 168 (1). pp. 51-57.
 
Relation http://dx.doi.org/10.1016/0006-291X(90)91673-G
http://www.eprints.iicb.res.in/947/