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Acivlcin : A Highly Active Potential Chemotherapeutic Agent against Visceral Leishmaniasis.

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Title Acivlcin : A Highly Active Potential Chemotherapeutic Agent against Visceral Leishmaniasis.
 
Creator Mukherjee, Tanmoy
Roy, Krishnendu
Bhaduri, Amar Nath
 
Subject Infectious Diseases and Immunology
 
Description Acivicin, a chlorinated amino acid antibiotic, is found to be
remarkably effective in killing both the vector and the host form of
the parasitic protozoa, Leishmania donovani, the causative agent for visceral
leishmaniasis or Kala-azar. The ED50 (50 nM1 for the pathogenic
amastigote form in invitro screening system is significantly lower than
the reported values for other drugs under trial. The drug irreversibly
inactivates both in vitro and in vivo carbamyl phosphate synthetase II,
the first enzyme of the pyrimidine biosynthetic pathway. The irreversible
inactivation of this sensitive target enzyme and lack of effective
reversal by glutamine makes acivicin a preferred candidate for potential
chemotherapy against increasing number of Kala-azar cases that are reported
to be unresponsive to pentavalent antimonials.
 
Publisher Elsevier
 
Date 1990
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/952/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS__170(_2)_426%2D432;1990[25].pdf
Mukherjee, Tanmoy and Roy, Krishnendu and Bhaduri, Amar Nath (1990) Acivlcin : A Highly Active Potential Chemotherapeutic Agent against Visceral Leishmaniasis. Biochemical and Biophysical Research Communications, 170 (2). pp. 426-432.
 
Relation http://dx.doi.org/10.1016/0006-291X(90)92109-D
http://www.eprints.iicb.res.in/952/