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Synthesis, Cytotoxicity, and Structure–Activity Relationship (SAR) Studiesn of Andrographolide Analogues as Anti-Cancer Agent

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Title Synthesis, Cytotoxicity, and Structure–Activity Relationship (SAR) Studiesn of Andrographolide Analogues as Anti-Cancer Agent
 
Creator Das, Bimolendu
Chowdhury, Chinmay
Kumar, Deepak
Sen, Rupashree
Roy, Rajneeta
Das, Padma
Chatterjee, Mitali
 
Subject Cell Biology & Physiology
 
Description A series of analogues of andrographolide, prepared through chemo-selective functionalization at C14
hydroxy, have been evaluated for in vitro cytotoxicities against human leukemic cell lines. Two of the
analogues (6a, 9b) exhibited significant potency. Preliminary studies on structure–activity relationship
(SAR) revealed that the a-alkylidene-c-butyrolactone moiety of andrographolide played a major role in
the activity profile. The structures of the analogues were established through spectroscopic and analytical
data
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/964/1/7_bmcl_2010.pdf
Das, Bimolendu and Chowdhury, Chinmay and Kumar, Deepak and Sen, Rupashree and Roy, Rajneeta and Das, Padma and Chatterjee, Mitali (2010) Synthesis, Cytotoxicity, and Structure–Activity Relationship (SAR) Studiesn of Andrographolide Analogues as Anti-Cancer Agent. Bioorganic & Medicinal Chemistry Letters, 20 (23). pp. 6947-6950.
 
Relation http://dx.doi.org/10.1016/j.bmcl.2010.09.126
http://www.eprints.iicb.res.in/964/