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Identification of a Sulfonoquinovosyldiacylglyceride from Azadirachta Indica and Studies on its Cytotoxic Activity and DNA Binding Properties

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Title Identification of a Sulfonoquinovosyldiacylglyceride from Azadirachta Indica and Studies on its Cytotoxic Activity and DNA Binding Properties
 
Creator Chatterjee, Ratna
Singh, Omkar
Pachuau, Lalawmpuii
Malik, Shiba Prasad
Paul, Mausumi
Bhadra, Kakali
Paul, Santanu
Kumar, G Suresh
Mondal, Nirup B
Banerjee, Sukdeb
 
Subject Chemistry
 
Description Chromatographic separation of the methanolic extract of the leaves of Azadirachta indica led to the isolation
of a sulfonoglycolipid characterized as a sulfonoquinovosyldiacylglyceride (SQDG), by extensive
2D NMR and mass spectral analysis. SQDG induces apoptosis in a dose dependent manner with IC50
8.3 lM against acute lymphoblastic leukemia (ALL) MOLT-4 cell lines. The compound showed significant
DNA binding properties as evidenced by the enhancement of melting temperature and perturbation of
the characteristic B-form in CD evidence of calf thymus DNA. The DNA binding was also characterized
by isothermal calorimetry where a predominantly enthalpy driven binding to CT DNA was revealed.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/969/1/10_bmcl_2010.pdf
Chatterjee, Ratna and Singh, Omkar and Pachuau, Lalawmpuii and Malik, Shiba Prasad and Paul, Mausumi and Bhadra, Kakali and Paul, Santanu and Kumar, G Suresh and Mondal, Nirup B and Banerjee, Sukdeb (2010) Identification of a Sulfonoquinovosyldiacylglyceride from Azadirachta Indica and Studies on its Cytotoxic Activity and DNA Binding Properties. Bioorganic & Medicinal Chemistry Letters, 20 (22). pp. 6699-6702.
 
Relation http://dx.doi.org/10.1016/j.bmcl.2010.09.007
http://www.eprints.iicb.res.in/969/