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Effect of Increase in Orientational Order of Lipid Chains and Head Group Spacing on Non Steroidal Anti-Inflammatory Drug Induced Membrane Fusion

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Title Effect of Increase in Orientational Order of Lipid Chains and Head Group Spacing on Non Steroidal Anti-Inflammatory Drug Induced Membrane Fusion
 
Creator Mondal Roy, Sutapa
Bansode, Amol S
Sarkar, Munna
 
Subject Chemistry
 
Description Membrane fusion is a key event in many biological processes. The fusion process, both in vivo and in vitro, is induced
by different agents which include mainly proteins and peptides. For protein- and peptide-mediated membrane fusion,
conformational reorganization serves as a driving force. Small drug molecules do not share this advantage; hence, drug
induced membrane fusion occurring in absence of any other fusogenic agent and at physiologically relevant
concentration of the drugs is a very rare event. To date, only three drugs, namely, meloxicam (Mx), piroxicam (Px),
and tenoxicam (Tx), belonging to the oxicam group of non steroidal anti-inflammatory drugs (NSAIDs), have been
shown by us to induce fusion at very low drug to lipid ratio without the aid of any other fusogenic agent. In our
continued effort to understand the interplay of different physical and chemical parameters of both the participating
drugs and the membrane on the mechanism of this drug induced membrane fusion, we present here the effect of increase
in orientational order of the lipid chains and increase in head group spacing. This is achieved by studying the effect of low
concentration cholesterol (
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1012/1/2_LANG_2010.pdf
Mondal Roy, Sutapa and Bansode, Amol S and Sarkar, Munna (2010) Effect of Increase in Orientational Order of Lipid Chains and Head Group Spacing on Non Steroidal Anti-Inflammatory Drug Induced Membrane Fusion. Langmuir, 26 (24). pp. 18967-18975.
 
Relation http://dx.doi.org/10.1021/la103802d
http://www.eprints.iicb.res.in/1012/