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Isoquinoline Alkaloids and Basis of Therapeutic Action

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Title Isoquinoline Alkaloids and Basis of Therapeutic Action
 
Creator Giri, Prabal
Kumar, G Suresh
 
Subject Chemistry
 
Description After fifty years of DNA targeting through intercalators and groove binders and related studies now the current
focus is in RNA targeting. Polyadenylic acid [poly(A)] tail of mRNA has been recently established as a potential drug target
due to its significant role in the initiation of translation, maturation and stability of mRNA as well as in the production
of alternate proteins in eukaryotic cells. Isoquinoline group of alkaloids have their importance in contemporary biomedical
research and drug discovery programme due to extensive pharmacological and biological activity. Very recently some
small molecule alkaloids of the isoquinoline group have been found to bind poly(A) with remarkably high affinity leading
to self structure formation. These alkaloids have a high binding affinity towards single stranded poly(A) whereas their
binding with double stranded poly(A) is weak. Among the alkaloids discussed here, berberine and coralyne are found to be
capable inducing self-structure in poly(A). All the binding phenomena are characterized by electrostatic interaction between
RNA and the alkaloids and the mode of binding was revealed as either as full or partial intercalation. This review focuses
on the structural and biological significance of poly(A) and the recent developments in the use of plant alkaloids and their
synthetic analogs to control the structure and function of this RNA for the development of new alkaloid based molecules
specifically targeted to poly(A) structures.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1029/1/111_MRMC%2D10%2D7%2DKumar.pdf
Giri, Prabal and Kumar, G Suresh (2010) Isoquinoline Alkaloids and Basis of Therapeutic Action. Mini-Reviews in Medicinal Chemistry, 10. pp. 568-577.
 
Relation http://dx.doi.org/
http://www.eprints.iicb.res.in/1029/