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Hypothyroidism in the Developing Rat Brain is Associated with Marked Oxidative Stress and Aberrant Intraneuronal Accumulation of Neurofilaments

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Title Hypothyroidism in the Developing Rat Brain is Associated with Marked Oxidative Stress and Aberrant Intraneuronal Accumulation of Neurofilaments
 
Creator Rahaman, Sk. Ohidar
Ghosh, Sudakshina
Mohanakumar, K P
Das, Sumantra
Sarkar, Pranab K
 
Subject Cell Biology & Physiology
 
Description The effects of hypothyroidism on parameters of oxidative stress and on intraneuronal distribution of neurofilaments have been
investigated in the developing rat brain. Progressive hypothyroidism during the first 4 weeks of postnatal development led to an
increase in superoxide dismutase and catalase activity, decline in the level of glutathione and mitochondrial cytochrome c oxidase
activity and increase in the level of �OH radical along with enhanced protein carbonylation and lipid peroxidation. Immunocytochemical
staining of cryostat sections of normal and hypothyroid cerebella from 25 day postnatal rats with anti neurofilament
(NF) light chain (L) antibody showed aberrant accumulation of neurofilaments in the perikaryon of the hypothyroid Purkinje
neurons in contrast to relatively uniform distribution in the controls. The morphological and biochemical alterations in the
neurons of the developing hypothyroid brain are comparable to those seen in several neurodegenerative diseases. © 2001 Elsevier
Science Ireland Ltd and the Japan Neuroscience Society.
 
Date 2001
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1032/1/2001%2DNeurosci.Res..pdf
Rahaman, Sk. Ohidar and Ghosh, Sudakshina and Mohanakumar, K P and Das, Sumantra and Sarkar, Pranab K (2001) Hypothyroidism in the Developing Rat Brain is Associated with Marked Oxidative Stress and Aberrant Intraneuronal Accumulation of Neurofilaments. Neuroscience Research, 40. pp. 273-279.
 
Relation http://dx.doi.org/
http://www.eprints.iicb.res.in/1032/