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Self-Assembling Dipeptide-Based Nontoxic Vesicles as Carriers for Drugs and Other Biologically Important Molecules

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Title Self-Assembling Dipeptide-Based Nontoxic Vesicles as Carriers for Drugs and Other Biologically Important Molecules
 
Creator Naskar, Jishu
Roy, Subhasish
Joardar, Anindita
Das, Sumantra
Banerjee, Arindam
 
Subject Cell Biology & Physiology
 
Description Self-assembling short peptides can offer an opportunity to make useful nano-/microstructures that find
potential application in drug delivery. We report here the formation of multivesicular structures from
self-assembling water-soluble synthetic amphiphilic dipeptides containing a glutamic acid residue at the
C-terminus. These vesicular structures are stable over a wide range of pH (pH 2–12). However, they are
sensitive towards calcium ions. This causes the rupturing of these vesicles. Interestingly, these vesicles
can not only encapsulate an anticancer drug and a fluorescent dye, but also can release them in the
presence of calcium ions. Moreover, these multivesicular structures have the potential to carry
biologically important molecules like cyclic adenosine monophosphate (cAMP) within the cells keeping
their biological functions intact. A MTT cell-survival assay suggests the almost nontoxic nature of
these vesicles. Thus, these peptide vesicles can be used as biocompatible delivery vehicles for carrying
drugs and other bioactive molecules.
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1037/1/2011%2DOBC.pdf
Naskar, Jishu and Roy, Subhasish and Joardar, Anindita and Das, Sumantra and Banerjee, Arindam (2011) Self-Assembling Dipeptide-Based Nontoxic Vesicles as Carriers for Drugs and Other Biologically Important Molecules. Organic & Biomolecular Chemistry, 9. pp. 6610-6615.
 
Relation http://dx.doi.org/10.1039/c1ob05757j
http://www.eprints.iicb.res.in/1037/