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Anti-inflammatory activity of tea (Camellia sinensis) root extract

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Title Anti-inflammatory activity of tea (Camellia sinensis) root extract
 
Creator Chattopadhyay, P
Besra, S E
Gomes, Aparna
Das, M
Sur, P
Mitra, S
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description Pharmacological studies were carried out with methanol-water (1:1) extract of dried tea (Camellia sinensis) root
extract (TRE). TRE was found to possess anti-inflammatory, analgesic and antipyretic activities at 1/10th of its
LD50 dose of 100 mg/kg i.p. It was found that TRE inhibited the arachidonic acid-induced paw oedema in rats
which indicated that TRE produced the anti-inflammatory activity by inhibiting both the cyclooxygenase and
lypooxygenase pathways of arachidonic acid metabolism. TRE also enhanced peritoneal cell count and the number
of macrophages in normal mice. It is plausible that the saponins present in TRE may be responsible for these
activities of TRE.
 
Publisher Elsevier
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1051/1/42_LS_2004.pdf
Chattopadhyay, P and Besra, S E and Gomes, Aparna and Das, M and Sur, P and Mitra, S (2004) Anti-inflammatory activity of tea (Camellia sinensis) root extract. Life Sciences, 74. pp. 1839-1849.
 
Relation http://dx.doi.org/10.1016/j.lfs.2003.07.053
http://www.eprints.iicb.res.in/1051/