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Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders

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Title Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders
 
Creator Mukhopadhyay, Arijit
Talukdar, Sangita
Bhattacharjee, Ashima
Ray, Kunal
 
Subject Molecular & Human Genetics
 
Description To identify olfactomedin domain containing proteins, which are expressed in the eye and have similarity to
myocilin, to test as potential candidates for eye diseases. Most of the mutations in myocilin causing primary open angle
glaucoma are located in the olfactomedin domain. In vitro experiments demonstrated interaction between optimedin and
myocilin through the conserved olfactomedin domains of the proteins in rats, and it was speculated that optimedin might
have a role in the pathogenesis of ocular disorders. Hence, we aimed to identify myocilin related human proteins having
conserved olfactomedin domains with potential to interact between them and examine the expression patterns in the eye
by bioinformatics approaches. This endeavor would have the potential to identify new candidate genes for eye diseases in general and glaucoma in particular to be tested by wet-lab experiments.
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1052/1/34_MV_2004.pdf
Mukhopadhyay, Arijit and Talukdar, Sangita and Bhattacharjee, Ashima and Ray, Kunal (2004) Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders. Molecular Vision, 10. pp. 304-314.
 
Relation http://www.molvis.org/molvis/v10/a39
http://www.eprints.iicb.res.in/1052/