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Mast cells at the host–pathogen interface: host-protection versus immune evasion in leishmaniasis

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Title Mast cells at the host–pathogen interface: host-protection
versus immune evasion in leishmaniasis
 
Creator Saha, Bhaskar
Tonkal, A M D J
Croft, S
Roy, Siddhartha
 
Subject Structural Biology & Bioinformatics
 
Description Infection of a susceptible host with
Leishmania
, a protozoan parasite, causes the disease leishmaniasis,
which is characterized by neutrophil, eosinophil, macrophage, lymphocyte and mast cell infiltration into
the infected tissue followed by parasite growth. Although the roles played by other cells in leishmaniasis
are known, the role of mast cells remains to be ascertained. Here, we demonstrate that
Leishmania
regulates
mast cell infiltration to the site of infection, mast cell production and mast cell function resulting
in differential growth of the parasite in resistant (C57BL/6 or CBA/T6T6) and susceptible (BALB/c)
macrophages. An interleukin-3-dependent augmentation in mast cell committed progenitors is observed
in BALB/c but not in C57BL/6 mice during
Leishmania infection. The mast cell supernatants inhibit
IFNg -dependent restriction of Leishmania
growth in macrophages in BALB/c mice whereas the reverse
phenomenon occurs in C57BL/6 mice. Our data reveals a different facet of host–pathogen interaction.
 
Publisher Blackwell Publishing Ltd
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1058/1/26_CEI_2004.pdf
Saha, Bhaskar and Tonkal, A M D J and Croft, S and Roy, Siddhartha (2004) Mast cells at the host–pathogen interface: host-protection versus immune evasion in leishmaniasis. Clinical & Experimental Immunology, 137 (1). pp. 19-23.
 
Relation http://dx.doi.org/10.1111/j.1365-2249.2004.02505.x
http://www.eprints.iicb.res.in/1058/