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Protein A – a new ligand for human C-reactive protein

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Title Protein A – a new ligand for human C-reactive protein
 
Creator Das, Tanusree
Mandal, Chhabinath
Mandal, Chitra
 
Subject Cancer Biology and Inflammatory Disorder Division
 
Description Phosphorylcholine (PC) is a classical ligand of Creactive
protein (CRP), a clinically important acute phase
protein. In search of new ligands, CRPs were affinity-purified from several pathological samples, which exhibited distinct molecular variants induced in different diseases. Both glycosylated and non-glycosylated CRPs showed calcium-independent differential-binding to Staphylococcus aureus cell-surface Protein A. CRP possesses separate binding sites for Protein A and PC with different binding constants. We have demonstrated that Protein A is another ligand in addition to PC establishing an
extended definition of CRP. Protein A binding may impart
immunomodulatory roles of CRP in combating microorganisms
or other foreign materials.
 
Publisher Elsevier
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1063/1/8_FL_2004.pdf
Das, Tanusree and Mandal, Chhabinath and Mandal, Chitra (2004) Protein A – a new ligand for human C-reactive protein. FEBS Letters, 576. pp. 107-113.
 
Relation http://dx.doi.org/10.1016/j.febslet.2004.08.072
http://www.eprints.iicb.res.in/1063/