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Lipopolysaccharides of Vibrio cholerae II. Genetics of biosynthesis

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Title Lipopolysaccharides of Vibrio cholerae
II. Genetics of biosynthesis
 
Creator Chatterjee, S N
Chaudhuri, Keya
 
Subject Molecular & Human Genetics
 
Description An account of our up to date knowledge of the genetics of biosynthesis of Vibrio cholerae lipopolysaccharide (LPS) is presented in this
review. While not much information is available in the literature on the genetics of biosynthesis of lipid A of V. cholerae, the available
information on the characteristics and proposed functions of the corepolysaccharide (core-PS) biosynthetic genes is discussed. The genetic
organizations encoding the O-antigen polysaccharides (O-PS) of V. cholerae of serogroups O1 and O139, the disease causing ones, have been
described along with the putative functions of the different constituent genes. The O-PS biosynthetic genes of some non-O1, non-O139
serogroups, particularly the serogroups O37 and O22, and their putative functions have also been discussed briefly. In view of the importance of
the serogroup O139, the origination of the O139 strain and the possible donor of the corresponding O-PS gene cluster have been analyzed with a
view to having knowledge of (i) the mode of evolution of different serogroups and (ii) the possible emergence of pathogenic strain(s) belonging
to non-O1, non-O139 serogroups. The unsolved problems in this area of research and their probable impact on the production of an effective
cholera vaccine have been outlined in conclusion.
 
Publisher Elsevier
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1066/1/7_BBA_2004.pdf
Chatterjee, S N and Chaudhuri, Keya (2004) Lipopolysaccharides of Vibrio cholerae II. Genetics of biosynthesis. BBA - Biochimica et Biophysica Acta , 1690 (2). pp. 93-109.
 
Relation http://dx.doi.org/10.1016/j.bbadis.2004.06.006
http://www.eprints.iicb.res.in/1066/