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Nitric oxide donors protect against 1-methyl-4-phenyl pyridinium-induced experimental parkinsonism in rats: evidence for antioxida

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Title Nitric oxide donors protect against 1-methyl-4-phenyl
pyridinium-induced experimental parkinsonism in rats:
evidence for antioxida
 
Creator Banerjee, R
Sarvanan, K S
Sindhu, Kizhake M
Mohanakumar, K P
 
Subject Cell Biology & Physiology
 
Description Nitric oxide (NO) with free radical properties plays a controversial critical
role under a variety of physiologic and pathologic conditions. We
investigated the effects of NO donors such as S-nitroso-N-acetylpenicillamine
(SNAP), 3-morpholinosydnonimine hydrochloride (SIN-1), sodium
nitroprusside (SNP) and nitroglycerin (NG) in nigrostriatal dopaminergic
toxicity caused by the potent parkinsonian neurotoxin, 1-methyl-4-phenylpyridinium
(MPP+) in vivo in rats and in MPP+ induced hydroxyl radical
(.OH) generation in mitochondria in vitro. NG, SNAP and SIN-1 caused
significant attenuation of MPP+ induced .OH generation in mitochondria.
Administration of MPP+ by intranigral infusion in rats to produce
nigrostriatal damage was significantly attenuated by co-infusion of NG,
SNAP and SIN-1 but not by SNP. NG, SNAP and SIN-1 exposed for 48 h to
remove NO when administered similarly, failed to protect against MPP+ induced neurotoxicity in vivo. Long-term exposed SNP when administered intranigrally, caused dose-dependent depletion of striatal dopamine. These results indicate that selective NO donors can protect dopaminergic neurotoxicity caused by MPP+ by releasing NO in the nigral region and by virtue of its OH scavenging action. This study warrants the neuroprotective
role of NO in dopaminergic neurodegeneration.
 
Date 2003
 
Type Conference or Workshop Item
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1072/1/3_4_JN_2003.pdf
Banerjee, R and Sarvanan, K S and Sindhu, Kizhake M and Mohanakumar, K P (2003) Nitric oxide donors protect against 1-methyl-4-phenyl pyridinium-induced experimental parkinsonism in rats: evidence for antioxida. In: Joint Meeting of the International-Society-for-Neurochemistry/Asian-Pacific-Society-for-Neurochemistry, WANCHAI, PEOPLES R CHINA.
 
Relation http://onlinelibrary.wiley.com/doi/10.1046/j.1474-1644.2003.2175_9.x/pdf
http://www.eprints.iicb.res.in/1072/