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A Simple One-Pot Entry to Cyclic Ethers of Varied Ring Sizes From Diols via Phosphonium Ion Induced Iodination and Base Catalyzed Williamson Etherification

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Title A Simple One-Pot Entry to Cyclic Ethers of Varied Ring Sizes From Diols via Phosphonium Ion Induced Iodination and
Base Catalyzed Williamson Etherification
 
Creator Roy, Biswajit Gopal
Roy, Ashim
Achari, Basudeb
Mandal, Sukhendu B
 
Subject Chemistry
 
Description A novel and an efficient one-pot cyclization method using triphenylphosphine, iodine and a nitrogenous base has
been established for the synthesis of cyclic ethers of various ring sizes. This appears to follow a two-step procedure, which includes
preferential substitution of one hydroxyl group by an iodide generated in situ followed by an intramolecular ring closure through the
attack of a free hydroxyl group or the more nucleophilic oxide ion.
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1091/1/TETRAHEDRON_LETTERS__Volume_47___Issue_44___Pages_7783%2D7787___[22].pdf
Roy, Biswajit Gopal and Roy, Ashim and Achari, Basudeb and Mandal, Sukhendu B (2006) A Simple One-Pot Entry to Cyclic Ethers of Varied Ring Sizes From Diols via Phosphonium Ion Induced Iodination and Base Catalyzed Williamson Etherification. Tetrahedron Letters, 47 (44). pp. 7783-7787.
 
Relation http://dx.doi.org/10.1016/j.tetlet.2006.08.090
http://www.eprints.iicb.res.in/1091/