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Compositional Variation in Bacterial Genes and Proteins With Potential Expression Level

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Title Compositional Variation in Bacterial Genes and Proteins
With Potential Expression Level
 
Creator Das, Sabyasachi
Ghosh, Subhagata
Pan, Archana
Dutta, Chitra
 
Subject Structural Biology & Bioinformatics
 
Description Abstract Usage of guanine and cytosine at three codon sites in eubacterial genes vary distinctly with potential expressivity, as npredicted by Codon Adaptation Index (CAI). In bacteria with moderate/high GC-content, G3 follows a biphasic relationship, while C3 increases with CAI. In AT-rich bacteria, correlation of CAI is negative with G3, but non-speci.c with C3. Correlations
of CAI with residues encoded by G-starting codons are
positive, while with those by C-starting codons are usually negative/ random. Average Size/Complexity Score and aromaticity of gene-products decrease with CAI, con.rming general validity of cost-minimization principle in free-living eubacteria. Alcoholicity of bacterial gene-products usually decreases with expressivity.
 
Date 2005
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1108/1/FEBS_LETTERS%2C_579(_23)%2C_5205%2D5210_[20].pdf
Das, Sabyasachi and Ghosh, Subhagata and Pan, Archana and Dutta, Chitra (2005) Compositional Variation in Bacterial Genes and Proteins With Potential Expression Level. FEBS Letters, 579 (23). pp. 5205-5210.
 
Relation http://dx.doi.org/10.1016/j.febslet.2005.08.042
http://www.eprints.iicb.res.in/1108/