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RNA Specific Molecules: Cytotoxic Plant Alkaloid Palmatine Binds Strongly to Poly(A)

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Title RNA Specific Molecules: Cytotoxic Plant Alkaloid Palmatine
Binds Strongly to Poly(A)
 
Creator Giri, Prabal
Hossain, Maidul
Kumar, G Suresh
 
Subject Chemistry
 
Description Abstract—The cytotoxic plant alkaloid palmatine was found to bind strongly by partial intercalation to single stranded poly(A) structure with binding affinity (Ka) of (8.36 ± 0.26) · 105 M�1. The binding of palmatine was characterized to be exothermic and enthalpy driven with one palmatine for every two adenine residues. On the other hand, the binding to the double stranded poly(A)
has been found to be significantly weak. This study identifies poly(A) as a potential bio-target for the alkaloid palmatine and its use as a lead compound in antitumor drug screening.
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1116/1/BIOORGANIC_%26_MEDICINAL_CHEMISTRY_LETTERS__Volume_16___Issue_9___Pages_2364%2D2368___[94].pdf
Giri, Prabal and Hossain, Maidul and Kumar, G Suresh (2006) RNA Specific Molecules: Cytotoxic Plant Alkaloid Palmatine Binds Strongly to Poly(A). Bioorganic & Medicinal Chemistry Letters, 16 (9). pp. 2364-2368.
 
Relation http://dx.doi.org/10.1016/j.bmcl.2006.01.124
http://www.eprints.iicb.res.in/1116/