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Daboia Russellii and Naja Kaouthia Venom Neutralization by Lupeol Acetate Isolated From the Root Extract of Indian Sarsaparilla Hemidesmus Indicus R.Br.

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Title Daboia Russellii and Naja Kaouthia Venom Neutralization by
Lupeol Acetate Isolated From the Root Extract of Indian
Sarsaparilla Hemidesmus Indicus R.Br.
 
Creator Chatterjee, Ipshita
Chakravarty, A K
Gomes, Aparna
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description The present study reports the isolation and purification of lupeol acetate from the methanolic root extract of Indian medicinal plant Hemidesmus
indicus (L.) R.Br. (family: Asclepiadaceae) which could neutralize venom induced action of Daboia russellii and Naja kaouthia on experimental
animals. Lupeol acetate could significantly neutralize lethality, haemorrhage, defibrinogenation, edema, PLA2 activity induced by Daboia russellii
venom. It also neutralized Naja kaouthia venom induced lethality, cardiotoxicity, neurotoxicity and respiratory changes in experimental animals.
Lupeol acetate potentiated the protection by snake venom antiserum action against Daboia russellii venom induced lethality in male albino mice.
Venom induced changes in lipid peroxidation and super oxide dismutase activity was antagonized by lupeol acetate. Snake venom neutralization
by lupeol acetate and its possible mechanism of action has been discussed.
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1118/1/JOURNAL_OF_ETHNOPHARMACOLOGY__Volume_106___Issue_1___Pages_38%2D43___[77].pdf
Chatterjee, Ipshita and Chakravarty, A K and Gomes, Aparna (2006) Daboia Russellii and Naja Kaouthia Venom Neutralization by Lupeol Acetate Isolated From the Root Extract of Indian Sarsaparilla Hemidesmus Indicus R.Br. Journal of Ethnopharmacology, 106 (1). pp. 38-43.
 
Relation http://dx.doi.org/10.1016/j.jep.2005.11.031
http://www.eprints.iicb.res.in/1118/