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Cytotoxic and Apoptogenic Effect of Tea (Camellia sinensis Var. assamica) Root Extract (TRE) and Two of Its Steroidal Saponins TS1 and TS2 on Human Leukemic Cell Lines K562 and U937 and on cells of CML and ALL Patients

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Title Cytotoxic and Apoptogenic Effect of Tea (Camellia sinensis Var. assamica) Root Extract (TRE) and Two of Its Steroidal Saponins TS1 and TS2 on Human Leukemic Cell Lines K562 and
U937 and on cells of CML and ALL Patients
 
Creator Ghosh, Papiya
Besra, Shila E
Tripathi, Gayatri
Mitra, Smita
Vedasiromoni, J R
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description The anticancer activity of di- and tri-terpenes and other polyphenolic compounds present in tea is already reported. We evaluated the cytotoxic and apoptogenic effect of tea root extract (TRE) and two of its steroidal saponins named as TS1 and TS2, on human cell lines and on cells from leukemic patients. It was found that TRE, TS1 and TS2 significantly decreased cell count and that TRE caused apoptosis, as confirmed morphologically by confocal microscopy and by flow-cytometric analysis using Annexin-V FITC and propidium iodide (PI). Cell count and MTT assay in normal white blood cells (WBC) of healthy volunteers revealed that TRE produced insignificant reduction in cell
count and cytotoxicity.
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1120/1/LEUKEMIA_RESEARCH__Volume_30___Issue_4___Pages_459%2D468___[107].pdf
Ghosh, Papiya and Besra, Shila E and Tripathi, Gayatri and Mitra, Smita and Vedasiromoni, J R (2006) Cytotoxic and Apoptogenic Effect of Tea (Camellia sinensis Var. assamica) Root Extract (TRE) and Two of Its Steroidal Saponins TS1 and TS2 on Human Leukemic Cell Lines K562 and U937 and on cells of CML and ALL Patients. Leukemia Research, 30 (4). pp. 459-468.
 
Relation http://dx.doi.org/10.1016/j.leukres.2005.08.018
http://www.eprints.iicb.res.in/1120/