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Venom of Indian Monocellate Cobra and Russell’s Viper Show Anticancer Activity in Experimental Models.

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Title Venom of Indian Monocellate Cobra and Russell’s Viper Show
Anticancer Activity in Experimental Models.
 
Creator Debnath, Anindita
Chatterjee, Uttora
Das, Minati
Vedasiromoni, J R
Gomes, Aparna
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description Indian monocellate cobra (Naja kaouthia) and Russell’s viper (Vipera russelli) are common snakes of the East Indian sub-peninsula. The anticarcinogenic activities of their crude venoms were studied on carcinoma, sarcoma and leukemia models. Sub-lethal doses of venoms showed
cytotoxicity on Ehrlich ascites carcinoma (EAC) cells in vivo. The venoms increased lifespan of EAC mice and strengthened the impaired host antioxidant system. Sarcoma formation in mice (3-methylcholanthrene induced) after venom treatment was significantly less (p < 0.005).
Histopathological examination of tumors showed tissue necrosis. The venoms displayed potent cytotoxic and apoptogenic effect on human leukemic cells (U937/K562). The venoms reduced cell proliferation rate (p < 0.005) and produced morphological alterations indicative of apoptosis induction. Different degree and nature of anticarcinogenic property of cobra and viper venoms may be attributed to the difference in their constituents.
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1140/1/JOURNAL_OF_ETHNOPHARMACOLOGY__111(_3)_681%2D684;2007[84].pdf
Debnath, Anindita and Chatterjee, Uttora and Das, Minati and Vedasiromoni, J R and Gomes, Aparna (2007) Venom of Indian Monocellate Cobra and Russell’s Viper Show Anticancer Activity in Experimental Models. Journal of Ethnopharmacology, 111 (3). pp. 681-684.
 
Relation http://dx.doi.org/:10.1016/j.jep.2006.12.027
http://www.eprints.iicb.res.in/1140/